Blood-brain Barrier Breached

Cornell University researchers may have solved a 100-year puzzle: How to safely open and close the blood-brain barrier so that therapies to treat Alzheimer’s disease, multiple sclerosis and cancers of the central nervous system might effectively be delivered.
- ScienceDaily – Sep. 13, 2011

This research was performed on mice; however, researchers have already found that humans like mice produce a molecule called adenosine and findings show that adenocine receptors can be activated to open and close the blood-brain barrier in both mice as well as humans. This means drug therapies, which currently are blocked on a molecular level by the blood-brain barrier, could be allowed to pass through increasing their effectiveness.

Adenosine has previously been FDA-approved for use in humans (currently for heart imaging). Could this provide a shortcut for researchers and drug developers?  It will be interesting to see.

Read the Science Daily article here: Breaching the blood-brain barrier: Finding may permit drug delivery to the brain for Alzheimer’s, multiple sclerosis and brain cancers.

Article Review: Letting Go of My Father – The Atlantic

by Michael J. Milazzo

The article, Letting Go of My Father, authored by Jonathan Rauch and originally published on April 2010 in The Atlantic, was recently presented by a member of one of AMI’s family caregiver support groups.   She explained that this article gave her the words that she had been trying to find but unable to form. This voice by proxy seems not only the author’s intent, but also a request.He lays out his own journey, unprepared, into care giving for his sick 80 year old father.  Mr. Rauch’s account zig-zags through the difficult processes that both providing care and accepting help demand, while it voices the isolation that family care givers often feel when they think their only choice is to go it alone.

I emerged from the whole experience not a little indignant. The medical infrastructure for elder care in America is good, very good. But the cultural infrastructure is all but nonexistent. How can it be that so many people like me are so completely unprepared for what is, after all, one of life’s near certainties?

Mr. Rauch estimates “millions of middle-aged Americans” need to be informed and supported but instead remain “invisible caregivers.” Rauch says the care giver’s silent problems are likely to require a cultural change; one he compellingly likens to Betty Fredan’s book, The Feminist Mystique, where “suddenly they realize they all share the same problem, the problem that has no name.”

. . . Well worth the read . . .  Link to the article: Letting Go of My Father – The Atlantic.

Can Television Be a Dementia Activity?

by Michael J. Milazzo

Wipeout LogoToday, I learned that the ABC game game show, Wipeout is a major hit among several of the residents in one San Francisco assisted living dementia community. It is 8:30 PM and most residents are either already in or on their way to bed. It is a time so quiet in most assisted living communities that one might think the building has been evacuated. I am here late checking on a resident who has trouble sleeping through the night; keeping her up past 9:00 PM helps to minimize late-night wandering which is often accompanied by heightened confusion and paranoid delusions. Continue reading